Development and validation of a risk prediction score for patients with nasopharyngeal carcinoma
نویسندگان
چکیده
Abstract Background We aimed to develop and validate a predictive model for the overall survival (OS) of patients with nasopharyngeal carcinoma (NPC). Methods Overall, 519 were retrospectively reviewed in this study. In addition, random forest was used identify significant prognostic factors OS among NPC patients. Then, calibration plot concordance index (C-index) utilized evaluate accuracy nomogram model. Results select three most important features, dNLR, HGB EBV DNA, which significantly associated Furthermore, C-index our 0.733 (95% CI 0.673 ~ 0.793) 0.772 0.691 0.853) two cohorts, higher than that TNM stage, treatment, DNA. Based on risk score, divided into groups, low-risk high-risk. Kaplan–Meier curves demonstrated subgroups primary cohort, as well validation cohort. The established using stage DNA cohorts. achieved 0.783 0.730 0.836) score cohort ( P = 0.005). Conclusions resulted more accurate prediction individual patient NPC.
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2021
ISSN: ['1475-2867']
DOI: https://doi.org/10.1186/s12935-021-02158-6